Research focus

Dr. Jake Michaelson's lab studies the effect of genetic variations on the development of the brain, with specific applications in autism and language impairment.

Courses taught

Selected publications / active grants

• Brueggeman, L., Koomar, T. & Michaelson, J. J. (null). Forecasting autism gene discovery with machine learning and genome-scale data. Cold Spring Harbor Laboratory. DOI: 10.1101/370601.
• Loguercio, S., Overall, R. W., Michaelson, J. J., Wiltshire, T., Pletcher, M. T., Miller, B. H., Walker, J. R., Kempermann, G., Su, A. I. & Beyer, A. (null). Integrative analysis of low- and high-resolution eQTL. PLoS One 5 (11) e13920. PMID: 21085707.
• Vervier, K. & Michaelson, J. J. (null). TiSAn: Estimating Tissue Specific Effects of Coding and Noncoding Variants. Bioinformatics. DOI: 10.1093/bioinformatics/bty301.
• Koomar, T. & Michaelson, J. J. (2020). Genetic Intersections of Language and Neuropsychiatric Conditions. Current Psychiatry Reports 22 (1). DOI: 10.1007/s11920-019-1123-z.
• Feliciano, P., Zhou, X., Astrovskaya, I., Turner, T. N., Wang, T., Brueggeman, L., Barnard, R., Hsieh, A., Snyder, L. G., Muzny, D. M., Sabo, A., Gibbs, R. A., Eichler, E. E., O’Roak, B. J., Michaelson, J. J., Volfovsky, N., Shen, Y. & Chung, W. K. (2019). Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes. npj Genomic Medicine 4 (1). DOI: 10.1038/s41525-019-0093-8.
• Dogan, M. V., Grumbach, I. M., Michaelson, J. J. & Philibert, R. A. (2018). Integrated genetic and epigenetic prediction of coronary heart disease in the Framingham Heart Study. PloS one 13 (1) e0190549. PMID: 29293675. DOI: 10.1371/journal.pone.0190549.
• Feliciano, P., Daniels, A. M., Snyder, L. G., Beaumont, A., Camba, A., Esler, A., Gulsrud, A. G., Mason, A., Nicholson, A., Paolicelli, A. M., McKenzie, A. P., Rachubinski, A. L., Stephens, A. N., Simon, A. R., Gutierrez, A., Stedman, A., Shocklee, A. D., Swanson, A., Finucane, B., Hilscher, B. A., Hauf, B., O'Roak, B. J., McKenna, B., Robertson, B. E., Rodriguez, B., Vernoia, B. M., Van Metre, Bonnie, Bradley, C., Cohen, C., Erickson, C. A., Harkins, C., Hayes, C., Lord, C., Martin, C. L., Ortiz, C., Ochoa-Lubinoff, C., Peura, C., Rice, C. E., Rosenberg, C. R., Smith, C. J., Thomas, C., Taylor, C. M., Casey, L., Walston, White Corrie H., Amaral, D. G., Coury, D. L., Sarver, D. E., Istephanous, D., Li, D., Dzung Cong Nugyen, Fox, E. A., Butter, E. M., Berry-Kravis, E., Courchesne, E., Fombonne, E. J., Hofammann, E., Lamarche, E., Wodka, E. L., Matthews, E. T., O'Connor, E., Palen, E., Gwynette, M. F., Miller, F., Dichter, G. S., Marzano, G., Stein, G., Hutter, H., Kaplan, H. E., Li, H., Lechniak, H., Schneider, H. L., Zaydens, H., Arriaga, I., Gerdts, J. A., Cubells, J. F., Cordova, J. M., Gunderson, J., Lillard, J., Manoharan, J., McCracken, J. T., Michaelson, J. J., Neely, J., Orobio, J., Pandey, J., Piven, J., Scherr, J., Sutcliffe, J. S., Tjernagel, J., Wallace, J., Callahan, K., Dent, K., Schweers, K. A., Hamer, K. E., Law, J. K., Lowe, K., O'Brien, K., Smith, K., Pawlowski, K. G., Pierce, K. L., Roeder, K., Abbeduto, L. J., Berry, L. N., Cartner, L. A., Coppola, L. A., Carpenter, L., Cordeiro, L., DeMarco, L., Grosvenor, L. P., Higgins, L., Huang-Storms, L. Y., Hosmer-Quint, L., Herbert, L. M., Kasparson, L., Prock, L. M., Pacheco, L. D., Raymond, L., Simon, L., Soorya, L. V., Wasserburg, L., Lazar, M., Alessandri, M., Brown, M., Currin, M. H., Heyman, M., Hale, M. N., Jones, M., Jordy, M., Morrier, M. J., Sahin, M., Siegel, M. S., Verdi, M., Parlade, M. V., Yinger, M., Bardett, N., Hanna, N., Harris, N., Pottschmidt, N., Russo-Ponsaran, N., Takahashi, N., Ousley, O. Y., Juarez, A. P., Manning, P., Annett, R. D., Bernier, R. A., Clark, R. D., Landa, R. J., Goin-Kochel, R. P., Remington, R., Schultz, R. T., Brewster, S. J., Booker, S., Carpenter, S., Eldred, S., Francis, S., Friedman, S. L., Homer, S., Hepburn, S., Jacob, S., Kanne, S., Lee, S. J., Mastel, S. A., Plate, S., Qiu, S., Sandhu, S., Thompson, S., White, S., Myers, V. J., Singh, V., Yang, W. S., Warren, Z., Amatya, A., Ace, A. J., Chatha, A. S., Lash, A. E., Negron, B., Rigby, C., Ridenour, C., Stock, C. M., Schmidt, D., Fisk, I., Acampado, J., Nestle, J. L., Nestle, J. A., Layman, K., Butler, M. E., Kent, M., Mallardi, M. D., Carriero, N., Lawson, N., Volfovsky, N., Edgar, R., Marini, R., Rana, R., Ganesan, S., Shah, S., Ramsey, T., Chin, W., Jensen, W., Krentz, A. D., Gruber, A. J., Sabo, A., Salomatov, A., Eng, C., Muzny, D., Astrovskaya, I., Gibbs, R. A., Han, X., Shen, Y., Reichardt, L. F. & Chung, W. K. (2018). SPARK: A US Cohort of 50,000 Families to Accelerate Autism Research. (Vols. 97). (3), pp. 488-493. NEURON. DOI: 10.1016/j.neuron.2018.01.015.
• McKenna, B., Koomar, T., Vervier, K., Kremsreiter, J. & Michaelson, J. J. (2018). Whole-genome sequencing in a family with twin boys with autism and intellectual disability suggests multimodal polygenic risk. COLD SPRING HARBOR MOLECULAR CASE STUDIES 4 (6). DOI: 10.1101/mcs.a003285.
• Lutter, M., Bahl, E., Hannah, C., Hofammann, D., Acevedo, S., Cui, H., McAdams, C. J. & Michaelson, J. J. (2017). Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors. PLoS One 12 (8) e0181556.
• Vervier, K. & Michaelson, J. J. (2017). TiSAn: Estimating tissue-specific effects of genetic variants.